Every three years, the leaders of United Brethren National Conferences meet for General Conference. Each National Conference sends two representatives — its highest elected official, and one other person. Mission districts are typically represented by one person, who comes with advisory status only.

General Conference has met in the following places:

2010: La Ceiba, Honduras.
2013: Kitchener, Ontario.
2017: Chambersburg, Pa.

The 2020 General Conference was scheduled to meet in Jamaica, but the pandemic forced it to be postponed. The next General Conference will probably be held in 2022 in Jamaica.