Every three years, the leaders of United Brethren National Conferences meet for General Conference. Each National Conference sends two representatives — its highest elected official, and one other person. Mission districts are typically represented by one person, who comes with advisory status only.

General Conference has met in the following places:

2010: La Ceiba, Honduras.
2013: Kitchener, Ontario.
2017: Chambersburg, Pa.
2020: Mandeville, Jamaica.